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Clinical Consultations and Guidelines

Mpox Resources

CDC - Guidance for Prevention and Treatment of Mpox in Persons with HIV Infection

The CDC developed clinical considerations for prevention and treatment of Mpox in persons with HIV infection, including pre-exposure and postexposure prophylaxis with JYNNEOS vaccine, treatment with tecovirimat, and infection control.

HRSA - Mpox Information

Keeping Ryan White HIV/AIDS Program recipients, subrecipients, and stakeholders up-to-date about Mpox (MPX) is a priority for HRSA. Please review these resources for the latest news and updates.

Hotlines and Referral Services


As a national health information hotline, it provides information such as how to protect yourself, where to get an HIV test, and other HIV related questions. In English or in Spanish from 8 am to 8 pm Eastern Time, Monday through Friday.

TTY: 1-888-232-6348


As a service of the US Department of Health and Human Services (HHS), specialists provide customized, confidential answers to  questions about HIV/AIDS clinical trials and treatment. . In English or in Spanish from 1 pm to 4 pm Eastern Time, Monday through Friday.

TTY: 1-888-480-3739

General Resources

For Clinicians Only

Clinician Consultation Center

A national resource for health care providers to obtain timely, expert and appropriate responses to clinical questions related to HIV/AIDS treatment. The four telephone consultation services are:

Clinicians' Warmline

Provides expert clinical advice on HIV/AIDS management for health care providers, from those with limited access to expert consultation to those with complex antiretroviral resistance dilemmas. From 9 am to 8 pm Eastern Time, Monday through Friday.


Provides expert guidance on considerations of providing PrEP to persons without HIV infection as part of an HIV prevention program. From 11 am to 6 pm Eastern Time, Monday through Friday.


Provides expert guidance in managing healthcare worker exposures to HIV and hepatitis B and C. Callers receive immediate postexposure prophylaxis recommendations. From 9 am to 9 pm Eastern Time, seven days a week.

Perinatal HIV Hotline

Provides 24/7 advice on indications and interpretations of standard and rapid HIV testing in pregnancy as well as consultation on antiretroviral use in pregnancy, labor and delivery, and the postpartum period.


Clinical Info

Provides links to the most current HIV prevention and treatment guidelines from HHS and CDC. Also includes guidance on caring or persons with HIV in disaster areas and interim guidance on COVID-19 and HIV and access to mobile app clinical tools.


Free, interactive tool to inform clinical decision-making for selecting ARV regimens.

HIVinfo Mobile Applications for Health Professionals

Provides three downloadable apps: HIV/AIDS clinical practice guidelines; Drug Database; and HIV/AIDS Glossary.

CDC 2021 STI Treatment Guidelines

CDC’s Sexually Transmitted Infections (STI) Treatment Guidelines, 2021 provides current evidence-based prevention, diagnostic and treatment recommendations that replace the 2015 guidance. The recommendations are intended to be a source for clinical guidance.