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Clinical Consultations and Guidelines

Mpox Resources

CDC - Guidance for Prevention and Treatment of Mpox in Persons with HIV Infection

The CDC developed clinical considerations for prevention and treatment of Mpox in persons with HIV infection, including pre-exposure and postexposure prophylaxis with JYNNEOS vaccine, treatment with tecovirimat, and infection control.

HRSA - Mpox Information

Keeping Ryan White HIV/AIDS Program recipients, subrecipients, and stakeholders up-to-date about Mpox (MPX) is a priority for HRSA. Please review these resources for the latest news and updates.

Hotlines and Referral Services

CDC – INFO

As a national health information hotline, it provides information such as how to protect yourself, where to get an HIV test, and other HIV related questions. In English or in Spanish from 8 am to 8 pm Eastern Time, Monday through Friday. 1-800-232-4636 TTY: 1-888-232-6348  

AIDSinfo

As a service of the US Department of Health and Human Services (HHS), specialists provide customized, confidential answers to  questions about HIV/AIDS clinical trials and treatment. . In English or in Spanish from 1 pm to 4 pm Eastern Time, Monday through Friday. 1-800-448-0440 TTY: 1-888-480-3739
General Resources

For Clinicians Only

National Clinician Consultation Center

A national resource for health care providers to obtain timely, expert responses to clinical questions related to managing HIV/AIDS treatment, HIV prevention (including PrEP/PEP), perinatal HIV, Hepatitis C, and substance use. 844-ASK-NCCC (275-6222). Phone lines are open from 7AM-5PM PST, Monday-Friday.
Perinatal expertise is available 24/7.

 

Clinical Info HIV.gov

Provides links to the most current HIV prevention and treatment guidelines from HHS and CDC. Also includes guidance on caring or persons with HIV in disaster areas and interim guidance on COVID-19 and HIV and access to mobile app clinical tools.

HIV-Assist

Free, interactive tool to inform clinical decision-making for selecting ARV regimens.

HIVinfo Mobile Applications for Health Professionals

Provides three downloadable apps: HIV/AIDS clinical practice guidelines; Drug Database; and HIV/AIDS Glossary.

DHHS 2025 Opportunistic Infection Guidelines

In 2025, DHHS released updated guidelines on the prevention and treatment of opportunistic infections in adults and adolescents with HIV.

CDC 2025 HIV PEP Guidelines

In 2025, the CDC released updated guidelines for HIV Post-Exposure Prophylaxis (PEP), providing the latest expert recommendations.

CDC Guidelines for Doxy-PEP

In 2024, the CDC released new guidelines for “Doxy-PEP,” the use of doxycycline post-exposure prophylaxis for bacterial Sexually Transmitted Infection prevention. You can access the guidelines here.

CDC 2021 STI Treatment Guidelines

CDC’s Sexually Transmitted Infections (STI) Treatment Guidelines, 2021 provides current evidence-based prevention, diagnostic and treatment recommendations that replace the 2015 guidance. The recommendations are intended to be a source for clinical guidance.